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CONTRASTING BEHAVIOR OF CONFORMATIONALLY LOCKED CARBOCYCLIC NUCLEOSIDES OF ADENOSINE AND CYTIDINE AS SUBSTRATES FOR DEAMINASES

In addition to the already known differences between adenosine deaminase (ADA) and cytidine deaminase (CDA) in terms of their tertiary structure, the sphere of Zn(+2) coordination, and their reverse stereochemical preference, we present evidence that the enzymes also differ significantly in terms of...

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Detalles Bibliográficos
Main Authors: Marquez, Victor E., Schroeder, Gottfried K., Ludek, Olaf R., Siddiqui, Maqbool A., Ezzitouni, Abdallah, Wolfenden, Richard
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2910114/
https://ncbi.nlm.nih.gov/pubmed/20183605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15257770903091904
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