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Synthesis of conformationally locked carbocyclic nucleoside phosphonates to probe the active site of HIV-1 RT
The conformationally locked carbocyclic nucleoside phosphonates 2 and 2′ and key intermediates for the synthesis of 3 and 3′ were prepared from a chiral cyclopentene derivative and epicholorohydrine, respectively. The structure of the nucleoside precursor 6 was confirmed by X-ray crystallography. Th...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2008
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2727548/ https://ncbi.nlm.nih.gov/pubmed/18776534 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nass/nrn315 |
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