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Synthesis of conformationally locked carbocyclic nucleoside phosphonates to probe the active site of HIV-1 RT

The conformationally locked carbocyclic nucleoside phosphonates 2 and 2′ and key intermediates for the synthesis of 3 and 3′ were prepared from a chiral cyclopentene derivative and epicholorohydrine, respectively. The structure of the nucleoside precursor 6 was confirmed by X-ray crystallography. Th...

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Bibliografische gegevens
Hoofdauteurs: Saneyoshi, Hisao, Vu, B. Christie, Hughes, Stephen H., Boyer, Paul L., Sarafianos, Stefan G., Marquez, Victor E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2008
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2727548/
https://ncbi.nlm.nih.gov/pubmed/18776534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nass/nrn315
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