Thioredoxin Reductase-2 Is Essential for Keeping Low Levels of H(2)O(2) Emission from Isolated Heart Mitochondria

Respiring mitochondria produce H(2)O(2) continuously. When production exceeds scavenging, H(2)O(2) emission occurs, endangering cell functions. The mitochondrial peroxidase peroxiredoxin-3 reduces H(2)O(2) to water using reducing equivalents from NADPH supplied by thioredoxin-2 (Trx2) and, ultimatel...

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Detalhes bibliográficos
Main Authors: Stanley, Brian A., Sivakumaran, Vidhya, Shi, Sa, McDonald, Iain, Lloyd, David, Watson, Walter H., Aon, Miguel A., Paolocci, Nazareno
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190932/
https://ncbi.nlm.nih.gov/pubmed/21832082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.284612
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