Thioredoxin Reductase-2 Is Essential for Keeping Low Levels of H(2)O(2) Emission from Isolated Heart Mitochondria

Respiring mitochondria produce H(2)O(2) continuously. When production exceeds scavenging, H(2)O(2) emission occurs, endangering cell functions. The mitochondrial peroxidase peroxiredoxin-3 reduces H(2)O(2) to water using reducing equivalents from NADPH supplied by thioredoxin-2 (Trx2) and, ultimatel...

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Main Authors: Stanley, Brian A., Sivakumaran, Vidhya, Shi, Sa, McDonald, Iain, Lloyd, David, Watson, Walter H., Aon, Miguel A., Paolocci, Nazareno
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2011
Ábhair:
Metabolism
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190932/
https://ncbi.nlm.nih.gov/pubmed/21832082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.284612
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