Thioredoxin Reductase-2 Is Essential for Keeping Low Levels of H(2)O(2) Emission from Isolated Heart Mitochondria

Respiring mitochondria produce H(2)O(2) continuously. When production exceeds scavenging, H(2)O(2) emission occurs, endangering cell functions. The mitochondrial peroxidase peroxiredoxin-3 reduces H(2)O(2) to water using reducing equivalents from NADPH supplied by thioredoxin-2 (Trx2) and, ultimatel...

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Библиографические подробности
Главные авторы: Stanley, Brian A., Sivakumaran, Vidhya, Shi, Sa, McDonald, Iain, Lloyd, David, Watson, Walter H., Aon, Miguel A., Paolocci, Nazareno
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2011
Предметы:
Metabolism
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190932/
https://ncbi.nlm.nih.gov/pubmed/21832082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.284612
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