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Impaired mitochondrial energy supply coupled to increased H(2)O(2) emission under energy/redox stress leads to myocardial dysfunction during Type I diabetes

In Type I diabetic (T1DM) patients, both peaks of hyperglycaemia and increased sympathetic tone probably contribute to impair systolic and diastolic function. However, how these stressors eventually alter cardiac function during T1DM is not fully understood. In the present study, we hypothesized tha...

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Vydáno v:Clin Sci (Lond)
Hlavní autoři: Tocchetti, Carlo G., Stanley, Brian A., Sivakumaran, Vidhya, Bedja, Djahida, O’Rourke, Brian, Paolocci, Nazareno, Cortassa, Sonia, Aon, Miguel A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6433379/
https://ncbi.nlm.nih.gov/pubmed/26186741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/CS20150204
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