Metabolic remodelling of glucose, fatty acid and redox pathways in the heart of type 2 diabetic mice

Type-2 diabetes (T2DM) leads to reduced myocardial performance, and eventually heart failure. Excessive accumulation of lipids and glucose is central to T2DM cardiomyopathy. Previous data showed that palmitate (Palm) or glutathione preserved heart mitochondrial energy/redox balance under excess gluc...

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Publicat a:J Physiol
Autors principals: Cortassa, Sonia, Caceres, Viviane, Tocchetti, Carlo G., Bernier, Michel, de Cabo, Rafael, Paolocci, Nazareno, Sollott, Steven J., Aon, Miguel A.
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7739175/
https://ncbi.nlm.nih.gov/pubmed/30462352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP276824
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