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Depletion of Cellular Glutathione Modulates LIF-Induced JAK1-STAT3 Signaling in Cardiac Myocytes

Previously we reported that the sesquiterpene lactone parthenolide induces oxidative stress in cardiac myocytes, which blocks Janus kinase (JAK) activation by the interleukin 6 (IL-6)-type cytokines. One implication suggested by this finding is that IL-6 signaling is dependent upon cellular anti-oxi...

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Detalhes bibliográficos
Main Authors: Kurdi, Mazen, Sivakumaran, Vidhya, Duhé, Roy J., Aon, Miguel A., Paolocci, Nazareno, Booz, George W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3496040/
https://ncbi.nlm.nih.gov/pubmed/22939972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biocel.2012.08.016
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