Acyloxy Nitroso Compounds Inhibit LIF Signaling in Endothelial Cells and Cardiac Myocytes: Evidence That STAT3 Signaling Is Redox-Sensitive

We previously showed that oxidative stress inhibits leukemia inhibitory factor (LIF) signaling by targeting JAK1, and the catalytic domains of JAK 1 and 2 have a cysteine-based redox switch. Thus, we postulated that the NO sibling and thiophylic compound, nitroxyl (HNO), would inhibit LIF-induced JA...

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Detalhes bibliográficos
Main Authors: Zgheib, Carlos, Kurdi, Mazen, Zouein, Fouad A., Gunter, Barak W., Stanley, Brian A., Zgheib, Joe, Romero, Damian G., King, S. Bruce, Paolocci, Nazareno, Booz, George W.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3419695/
https://ncbi.nlm.nih.gov/pubmed/22905257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043313
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