Postprandial Hepatic Lipid Metabolism Requires Signaling though Akt2 Independent of the Transcription Factors FoxA2, FoxO1 and SREBP1c

Under conditions of obesity and insulin resistance, the serine/threonine protein kinase Akt/PKB is required for lipid accumulation in liver. Two forkhead transcription factors, FoxA2 and FoxO1 have been suggested to function downstream of and to be negatively regulated by Akt and proposed as key det...

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Main Authors: Wan, Min, Leavens, Karla F., Saleh, Danish, Easton, Rachael M., Guertin, David A., Peterson, Timothy R., Kaestner, Klaus H., Sabatini, David M., Birnbaum, Morris J.
格式: Artigo
語言:Inglês
出版: 2011
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190164/
https://ncbi.nlm.nih.gov/pubmed/21982711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2011.09.001
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