Postprandial Hepatic Lipid Metabolism Requires Signaling though Akt2 Independent of the Transcription Factors FoxA2, FoxO1 and SREBP1c

Under conditions of obesity and insulin resistance, the serine/threonine protein kinase Akt/PKB is required for lipid accumulation in liver. Two forkhead transcription factors, FoxA2 and FoxO1 have been suggested to function downstream of and to be negatively regulated by Akt and proposed as key det...

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Главные авторы: Wan, Min, Leavens, Karla F., Saleh, Danish, Easton, Rachael M., Guertin, David A., Peterson, Timothy R., Kaestner, Klaus H., Sabatini, David M., Birnbaum, Morris J.
Формат: Artigo
Язык:Inglês
Опубликовано: 2011
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190164/
https://ncbi.nlm.nih.gov/pubmed/21982711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2011.09.001
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