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Direct measurement of the protein response to an electrostatic perturbation that mimics the catalytic cycle in ketosteroid isomerase

Understanding how electric fields and their fluctuations in the active site of enzymes affect efficient catalysis represents a critical objective of biochemical research. We have directly measured the dynamics of the electric field in the active site of a highly proficient enzyme, Δ(5)-3-ketosteroid...

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Bibliographische Detailangaben
Hauptverfasser: Jha, Santosh Kumar, Ji, Minbiao, Gaffney, Kelly J., Boxer, Steven G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3189056/
https://ncbi.nlm.nih.gov/pubmed/21949360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1113874108
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