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Quantitative, directional measurement of electric field heterogeneity in the active site of ketosteroid isomerase

Understanding the electrostatic forces and features within highly heterogeneous, anisotropic, and chemically complex enzyme active sites and their connection to biological catalysis remains a longstanding challenge, in part due to the paucity of incisive experimental probes of electrostatic properti...

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Detalhes bibliográficos
Main Authors: Fafarman, Aaron T., Sigala, Paul A., Schwans, Jason P., Fenn, Timothy D., Herschlag, Daniel, Boxer, Steven G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277571/
https://ncbi.nlm.nih.gov/pubmed/22308339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1111566109
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