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Quantitative, directional measurement of electric field heterogeneity in the active site of ketosteroid isomerase

Understanding the electrostatic forces and features within highly heterogeneous, anisotropic, and chemically complex enzyme active sites and their connection to biological catalysis remains a longstanding challenge, in part due to the paucity of incisive experimental probes of electrostatic properti...

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Autori principali: Fafarman, Aaron T., Sigala, Paul A., Schwans, Jason P., Fenn, Timothy D., Herschlag, Daniel, Boxer, Steven G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277571/
https://ncbi.nlm.nih.gov/pubmed/22308339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1111566109
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