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Quantitative, directional measurement of electric field heterogeneity in the active site of ketosteroid isomerase

Understanding the electrostatic forces and features within highly heterogeneous, anisotropic, and chemically complex enzyme active sites and their connection to biological catalysis remains a longstanding challenge, in part due to the paucity of incisive experimental probes of electrostatic properti...

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Hlavní autoři: Fafarman, Aaron T., Sigala, Paul A., Schwans, Jason P., Fenn, Timothy D., Herschlag, Daniel, Boxer, Steven G.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277571/
https://ncbi.nlm.nih.gov/pubmed/22308339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1111566109
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