Specificity and detection of insulin-reactive CD4(+) T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse

In the nonobese diabetic (NOD) mouse model of type 1 diabetes (T1D), an insulin peptide (B:9–23) is a major target for pathogenic CD4(+) T cells. However, there is no consensus on the relative importance of the various positions or “registers” this peptide can take when bound in the groove of the NO...

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Detaylı Bibliyografya
Asıl Yazarlar: Crawford, Frances, Stadinski, Brian, Jin, Niyun, Michels, Aaron, Nakayama, Maki, Pratt, Philip, Marrack, Philippa, Eisenbarth, George, Kappler, John W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2011
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3189014/
https://ncbi.nlm.nih.gov/pubmed/21949373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1113954108
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