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Monoclonal antibody blocking the recognition of an insulin peptide–MHC complex modulates type 1 diabetes
The primary autoantigen triggering spontaneous type 1 diabetes mellitus in nonobese diabetic (NOD) mice is insulin. The major T-cell insulin epitope lies within the amino acid 9–23 peptide of the β-chain (B:9–23). This peptide can bind within the peptide binding groove of the NOD MHC class II molecu...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3932899/ https://ncbi.nlm.nih.gov/pubmed/24550292 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1323436111 |
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