Monoclonal antibody blocking the recognition of an insulin peptide–MHC complex modulates type 1 diabetes

The primary autoantigen triggering spontaneous type 1 diabetes mellitus in nonobese diabetic (NOD) mice is insulin. The major T-cell insulin epitope lies within the amino acid 9–23 peptide of the β-chain (B:9–23). This peptide can bind within the peptide binding groove of the NOD MHC class II molecu...

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Hlavní autoři: Zhang, Li, Crawford, Frances, Yu, Liping, Michels, Aaron, Nakayama, Maki, Davidson, Howard W., Kappler, John W., Eisenbarth, George S.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2014
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3932899/
https://ncbi.nlm.nih.gov/pubmed/24550292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1323436111
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