Regulatory vs. inflammatory cytokine T-cell responses to mutated insulin peptides in healthy and type 1 diabetic subjects

Certain class II MHC (MHCII) alleles in mice and humans confer risk for or protection from type 1 diabetes (T1D). Insulin is a major autoantigen in T1D, but how its peptides are presented to CD4 T cells by MHCII risk alleles has been controversial. In the mouse model of T1D, CD4 T cells respond to i...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Nakayama, Maki, McDaniel, Kristen, Fitzgerald-Miller, Lisa, Kiekhaefer, Carol, Snell-Bergeon, Janet K., Davidson, Howard W., Rewers, Marian, Yu, Liping, Gottlieb, Peter, Kappler, John W., Michels, Aaron
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2015
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394309/
https://ncbi.nlm.nih.gov/pubmed/25831495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1502967112
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