T-cell responses to hybrid insulin peptides prior to type 1 diabetes development

T-cell responses to posttranslationally modified self-antigens are associated with many autoimmune disorders. In type 1 diabetes, hybrid insulin peptides (HIPs) are implicated in the T-cell–mediated destruction of insulin-producing β-cells within pancreatic islets. The natural history of the disease...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Mitchell, Angela M., Alkanani, Aimon A., McDaniel, Kristen A., Pyle, Laura, Waugh, Kathleen, Steck, Andrea K., Nakayama, Maki, Yu, Liping, Gottlieb, Peter A., Rewers, Marian J., Michels, Aaron W.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2021
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8017940/
https://ncbi.nlm.nih.gov/pubmed/33542101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2019129118
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