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Specificity and detection of insulin-reactive CD4(+) T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse
In the nonobese diabetic (NOD) mouse model of type 1 diabetes (T1D), an insulin peptide (B:9–23) is a major target for pathogenic CD4(+) T cells. However, there is no consensus on the relative importance of the various positions or “registers” this peptide can take when bound in the groove of the NO...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3189014/ https://ncbi.nlm.nih.gov/pubmed/21949373 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1113954108 |
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