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Diabetogenic T cells recognize insulin bound to IA(g7) in an unexpected, weakly binding register
A peptide derived from the insulin B chain contains a major epitope for diabetogenic CD4(+) T cells in the NOD mouse model of type 1 diabetes (T1D). This peptide can fill the binding groove of the NOD MHCII molecule, IA(g7), in a number of ways or “registers.” We show here that a diverse set of NOD...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2890771/ https://ncbi.nlm.nih.gov/pubmed/20534455 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1006545107 |
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