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Diabetogenic T cells recognize insulin bound to IA(g7) in an unexpected, weakly binding register

A peptide derived from the insulin B chain contains a major epitope for diabetogenic CD4(+) T cells in the NOD mouse model of type 1 diabetes (T1D). This peptide can fill the binding groove of the NOD MHCII molecule, IA(g7), in a number of ways or “registers.” We show here that a diverse set of NOD...

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Main Authors: Stadinski, Brian D., Zhang, Li, Crawford, Frances, Marrack, Philippa, Eisenbarth, George S., Kappler, John W.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890771/
https://ncbi.nlm.nih.gov/pubmed/20534455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1006545107
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