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Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallography
[Image: see text] Trypanothione reductase (TryR) is a genetically validated drug target in the parasite Trypanosoma brucei, the causative agent of human African trypanosomiasis. Here we report the discovery, synthesis, and development of a novel series of TryR inhibitors based on a 3,4-dihydroquinaz...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
American Chemical Society
2011
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| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3188286/ https://ncbi.nlm.nih.gov/pubmed/21851087 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200312v |
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