Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallography

[Image: see text] Trypanothione reductase (TryR) is a genetically validated drug target in the parasite Trypanosoma brucei, the causative agent of human African trypanosomiasis. Here we report the discovery, synthesis, and development of a novel series of TryR inhibitors based on a 3,4-dihydroquinaz...

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Autors principals: Patterson, Stephen, Alphey, Magnus S., Jones, Deuan C., Shanks, Emma J., Street, Ian P., Frearson, Julie A., Wyatt, Paul G., Gilbert, Ian H., Fairlamb, Alan H.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2011
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3188286/
https://ncbi.nlm.nih.gov/pubmed/21851087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200312v
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