Impaired Striatal Akt Signaling Disrupts Dopamine Homeostasis and Increases Feeding

BACKGROUND: The prevalence of obesity has increased dramatically worldwide. The obesity epidemic begs for novel concepts and therapeutic targets that cohesively address “food-abuse” disorders. We demonstrate a molecular link between impairment of a central kinase (Akt) involved in insulin signaling...

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Main Authors: Speed, Nicole, Saunders, Christine, Davis, Adeola R., Owens, W. Anthony, Matthies, Heinrich J. G., Saadat, Sanaz, Kennedy, Jack P., Vaughan, Roxanne A., Neve, Rachael L., Lindsley, Craig W., Russo, Scott J., Daws, Lynette C., Niswender1, Kevin D., Galli, Aurelio
格式: Artigo
語言:Inglês
出版: Public Library of Science 2011
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3182178/
https://ncbi.nlm.nih.gov/pubmed/21969871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0025169
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