Impaired Striatal Akt Signaling Disrupts Dopamine Homeostasis and Increases Feeding

BACKGROUND: The prevalence of obesity has increased dramatically worldwide. The obesity epidemic begs for novel concepts and therapeutic targets that cohesively address “food-abuse” disorders. We demonstrate a molecular link between impairment of a central kinase (Akt) involved in insulin signaling...

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Autores principales: Speed, Nicole, Saunders, Christine, Davis, Adeola R., Owens, W. Anthony, Matthies, Heinrich J. G., Saadat, Sanaz, Kennedy, Jack P., Vaughan, Roxanne A., Neve, Rachael L., Lindsley, Craig W., Russo, Scott J., Daws, Lynette C., Niswender1, Kevin D., Galli, Aurelio
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3182178/
https://ncbi.nlm.nih.gov/pubmed/21969871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0025169
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