Impaired Striatal Akt Signaling Disrupts Dopamine Homeostasis and Increases Feeding

BACKGROUND: The prevalence of obesity has increased dramatically worldwide. The obesity epidemic begs for novel concepts and therapeutic targets that cohesively address “food-abuse” disorders. We demonstrate a molecular link between impairment of a central kinase (Akt) involved in insulin signaling...

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Bibliografiska uppgifter
Huvudupphovsmän: Speed, Nicole, Saunders, Christine, Davis, Adeola R., Owens, W. Anthony, Matthies, Heinrich J. G., Saadat, Sanaz, Kennedy, Jack P., Vaughan, Roxanne A., Neve, Rachael L., Lindsley, Craig W., Russo, Scott J., Daws, Lynette C., Niswender1, Kevin D., Galli, Aurelio
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2011
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3182178/
https://ncbi.nlm.nih.gov/pubmed/21969871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0025169
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