Prolonged Survival and Phenotypic Correction of Akp2(−/−) Hypophosphatasia Mice by Lentiviral Gene Therapy

Hypophosphatasia (HPP) is an inherited systemic skeletal disease caused by mutations in the gene encoding the tissue-nonspecific alkaline phosphatase (TNALP) isozyme. The clinical severity of HPP varies widely, with symptoms including rickets and osteomalacia. TNALP knockout (Akp2(−/−)) mice phenoty...

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Bibliografiske detaljer
Main Authors: Yamamoto, Seiko, Orimo, Hideo, Matsumoto, Tae, Iijima, Osamu, Narisawa, Sonoko, Maeda, Takahide, Millán, José Luis, Shimada, Takashi
Format: Artigo
Sprog:Inglês
Udgivet: Wiley Subscription Services, Inc., A Wiley Company 2011
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3179312/
https://ncbi.nlm.nih.gov/pubmed/20687159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.201
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