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Prolonged Survival and Phenotypic Correction of Akp2(−/−) Hypophosphatasia Mice by Lentiviral Gene Therapy
Hypophosphatasia (HPP) is an inherited systemic skeletal disease caused by mutations in the gene encoding the tissue-nonspecific alkaline phosphatase (TNALP) isozyme. The clinical severity of HPP varies widely, with symptoms including rickets and osteomalacia. TNALP knockout (Akp2(−/−)) mice phenoty...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Wiley Subscription Services, Inc., A Wiley Company
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3179312/ https://ncbi.nlm.nih.gov/pubmed/20687159 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.201 |
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