Prenatal enzyme replacement therapy for Akp2(−/−) mice with lethal hypophosphatasia

Hypophosphatasia (HPP) is a congenital skeletal disease. Impairment of bone mineralization and seizures are due to a deficiency of tissue-nonspecific alkaline phosphatase (TNAP). Enzyme replacement therapy (ERT) is available as a highly successful treatment for pediatric-onset HPP. However, the pote...

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Vydáno v:Regen Ther
Hlavní autoři: Hasegawa, Akihiro, Nakamura-Takahashi, Aki, Kasahara, Masataka, Saso, Nana, Narisawa, Sonoko, Millán, José Luis, Samura, Osamu, Sago, Haruhiko, Okamoto, Aikou, Umezawa, Akihiro
Médium: Artigo
Jazyk:Inglês
Vydáno: Japanese Society for Regenerative Medicine 2021
Témata:
Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8267436/
https://ncbi.nlm.nih.gov/pubmed/34277899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.reth.2021.06.002
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