Rescue of Severe Infantile Hypophosphatasia Mice by AAV-Mediated Sustained Expression of Soluble Alkaline Phosphatase

Hypophosphatasia (HPP) is an inherited disease caused by a deficiency of tissue-nonspecific alkaline phosphatase (TNALP). The major symptom of human HPP is hypomineralization, rickets, or osteomalacia, although the clinical severity is highly variable. The phenotypes of TNALP knockout (Akp2(-/-)) mi...

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Detalhes bibliográficos
Main Authors: Matsumoto, Tae, Miyake, Koichi, Yamamoto, Seiko, Orimo, Hideo, Miyake, Noriko, Odagaki, Yuko, Adachi, Kumi, Iijima, Osamu, Narisawa, Sonoko, Millán, José Luis, Fukunaga, Yoshitaka, Shimada, Takashi
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2011
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3225041/
https://ncbi.nlm.nih.gov/pubmed/21388343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2010.210
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