Laddar...
Heterobiaryl and heterobiaryl ether derived M(5) positive allosteric modulators
This Letter describes a chemical lead optimization campaign directed at VU0238429, the first M(5)-preferring positive allosteric modulator (PAM), discovered through analog work around VU0119498, a pan G(q) mAChR M(1), M(3), M(5) PAM. An iterative parallel synthesis approach was employed to incorpora...
Sparad:
| Huvudupphovsmän: | , , , , |
|---|---|
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2010
|
| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3179183/ https://ncbi.nlm.nih.gov/pubmed/20801651 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.08.042 |
| Taggar: |
Lägg till en tagg
Inga taggar, Lägg till första taggen!
|