Heterobiaryl and heterobiaryl ether derived M(5) positive allosteric modulators

This Letter describes a chemical lead optimization campaign directed at VU0238429, the first M(5)-preferring positive allosteric modulator (PAM), discovered through analog work around VU0119498, a pan G(q) mAChR M(1), M(3), M(5) PAM. An iterative parallel synthesis approach was employed to incorpora...

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Detalhes bibliográficos
Main Authors: Bridges, Thomas M., Kennedy, J. Phillip, Hopkins, Corey R., Conn, P. Jeffrey, Lindsley, Craig W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3179183/
https://ncbi.nlm.nih.gov/pubmed/20801651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.08.042
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