Inflammasome is a central player in the induction of obesity and insulin resistance

Inflammation plays a key role in the pathogenesis of obesity. Chronic overfeeding leads to macrophage infiltration in the adipose tissue, resulting in proinflammatory cytokine production. Both microbial and endogenous danger signals trigger assembly of the intracellular innate immune sensor Nlrp3, r...

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Hauptverfasser: Stienstra, Rinke, van Diepen, Janna A., Tack, Cees J., Zaki, Md. Hasan, van de Veerdonk, Frank L., Perera, Deshani, Neale, Geoffrey A., Hooiveld, Guido J., Hijmans, Anneke, Vroegrijk, Irene, van den Berg, Sjoerd, Romijn, Johannes, Rensen, Patrick C. N., Joosten, Leo A. B., Netea, Mihai G., Kanneganti, Thirumala-Devi
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2011
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3174591/
https://ncbi.nlm.nih.gov/pubmed/21876127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1100255108
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