The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity

Obesity-induced inflammation originating from expanding adipose tissue interferes with insulin sensitivity. Important metabolic effects have been recently attributed to IL-1β and IL-18, two members of the IL-1 family of cytokines. Processing of IL-1β and IL-18 requires cleavage by caspase-1, a cyste...

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Main Authors: Stienstra, Rinke, Joosten, Leo A.B., Koenen, Tim, van Tits, Berry, van Diepen, Janna A., van den Berg, Sjoerd A.A., Rensen, Patrick C.N., Voshol, Peter J., Fantuzzi, Giamilla, Hijmans, Anneke, Kersten, Sander, Müller, Michael, van den Berg, Wim B., van Rooijen, Nico, Wabitsch, Martin, Kullberg, Bart-Jan, van der Meer, Jos W.M., Kanneganti, Thirumala, Tack, Cees J., Netea, Mihai G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3683568/
https://ncbi.nlm.nih.gov/pubmed/21109192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2010.11.011
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