Hyperglycemia Activates Caspase-1 and TXNIP-Mediated IL-1β Transcription in Human Adipose Tissue

OBJECTIVE: Obesity is characterized by elevated levels of proinflammatory cytokines, including interleukin (IL)-1β, that contribute to the development of insulin resistance. In this study, we set out to investigate whether hyperglycemia drives IL-1β production and caspase-1 activation in murine and...

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Detalhes bibliográficos
Main Authors: Koenen, Tim B., Stienstra, Rinke, van Tits, Lambertus J., de Graaf, Jacqueline, Stalenhoef, Anton F.H., Joosten, Leo A.B., Tack, Cees J., Netea, Mihai G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2011
Assuntos:
Obesity Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3028351/
https://ncbi.nlm.nih.gov/pubmed/21270263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-0266
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