Fatty acids engagement with TLR2 drive IL-1β production via ASC-caspase-1 pathway by urate crystals in gouty arthritis

OBJECTIVE: The concept that intraarticular crystals of uric acid of themselves trigger episodes of painful gouty arthritis is inconsistent with the clinical reality. Patients with large deposits of MSU crystals (tophi) do not necessarily suffer from gouty attacks. In fact, it is the excessive consum...

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Detalhes bibliográficos
Main Authors: Joosten, Leo A.B., Netea, Mihai G., Mylona, Eleni, Koenders, Marije I., Malireddi, R. K. Subbarao, Oosting, Marije, Stienstra, Rinke, van de Veerdonk, Frank L., Stalenhoef, Anton F., Giamarellos-Bourboulis, Evangelos J., Kanneganti, Thirumala-Devi, van der Meer, Jos W.M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2970687/
https://ncbi.nlm.nih.gov/pubmed/20662061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.27667
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