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Murine Borrelia arthritis is highly dependent on ASC and caspase-1, but independent of NLRP3
INTRODUCTION: The protein platform called the NOD-like-receptor -family member (NLRP)-3 inflammasome needs to be activated to process intracellular caspase-1. Active caspase-1 is able to cleave pro-Interleukin (IL)-1β, resulting in bioactive IL-1β. IL-1β is a potent proinflammatory cytokine, and tho...
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| Autores principales: | , , , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
BioMed Central
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3674595/ https://ncbi.nlm.nih.gov/pubmed/23148704 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar4090 |
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