Murine Borrelia arthritis is highly dependent on ASC and caspase-1, but independent of NLRP3

INTRODUCTION: The protein platform called the NOD-like-receptor -family member (NLRP)-3 inflammasome needs to be activated to process intracellular caspase-1. Active caspase-1 is able to cleave pro-Interleukin (IL)-1β, resulting in bioactive IL-1β. IL-1β is a potent proinflammatory cytokine, and tho...

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Main Authors: Oosting, Marije, Buffen, Kathrin, Malireddi, Subbarao RK, Sturm, Patrick, Verschueren, Ineke, Koenders, Marije I, van de Veerdonk, Frank L, van der Meer, Jos WM, Netea, Mihai G, Kanneganti, Thirumala-Devi, Joosten, Leo AB
Format: Artigo
Language:Inglês
Published: BioMed Central 2012
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674595/
https://ncbi.nlm.nih.gov/pubmed/23148704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar4090
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