Inflammasome-independent Role of Apoptosis-associated Speck-like Protein Containing a CARD (ASC) in T Cell Priming Is Critical for Collagen-induced Arthritis

Rheumatoid arthritis is an autoimmune disease with 1% prevalence in the industrialized world. The contributions of the inflammasome components Nlrp3, ASC, and caspase-1 in the pathogenesis of collagen-induced arthritis have not been characterized. Here, we show that ASC(−/−) mice were protected from...

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Detalhes bibliográficos
Main Authors: Ippagunta, Sirish K., Brand, David D., Luo, Jiwen, Boyd, Kelli L., Calabrese, Christopher, Stienstra, Rinke, Van de Veerdonk, Frank L., Netea, Mihai G., Joosten, Leo A. B., Lamkanfi, Mohamed, Kanneganti, Thirumala-Devi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2852983/
https://ncbi.nlm.nih.gov/pubmed/20177071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.093252
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