Structure and specificity of nuclear receptor–coactivator interactions

Combinatorial regulation of transcription implies flexible yet precise assembly of multiprotein regulatory complexes in response to signals. Biochemical and crystallographic analyses revealed that hormone binding leads to the formation of a hydrophobic groove within the ligand binding domain (LBD) o...

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Main Authors: Darimont, Beatrice D., Wagner, Richard L., Apriletti, James W., Stallcup, Michael R., Kushner, Peter J., Baxter, John D., Fletterick, Robert J., Yamamoto, Keith R.
格式: Artigo
語言:Inglês
出版: Cold Spring Harbor Laboratory Press 1998
主題:
Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC317236/
https://ncbi.nlm.nih.gov/pubmed/9808622
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