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Electrostatic Modulation in Steroid Receptor Recruitment of LXXLL and FXXLF Motifs
Coactivator recruitment by activation function 2 (AF2) in the steroid receptor ligand binding domain takes place through binding of an LXXLL amphipathic α-helical motif at the AF2 hydrophobic surface. The androgen receptor (AR) and certain AR coregulators are distinguished by an FXXLF motif that int...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology
2003
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC149467/ https://ncbi.nlm.nih.gov/pubmed/12612084 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.6.2135-2150.2003 |
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