Reciprocal activation of Xenobiotic response genes by nuclear receptors SXR/PXR and CAR

The cytochrome P450 (CYP) gene products such as CYP3A and CYP2B are essential for the metabolism of steroid hormones and xenochemicals including prescription drugs. Nuclear receptor SXR/PXR (steroid and xenobiotic receptor/pregnenolone X receptor) has been shown both biochemically and genetically to...

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Hauptverfasser: Xie, Wen, Barwick, Joyce L., Simon, Cynthia M., Pierce, Alexis M., Safe, Stephen, Blumberg, Bruce, Guzelian, Philip S., Evans, Ronald M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2000
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC317112/
https://ncbi.nlm.nih.gov/pubmed/11114890
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