Reciprocal activation of Xenobiotic response genes by nuclear receptors SXR/PXR and CAR

The cytochrome P450 (CYP) gene products such as CYP3A and CYP2B are essential for the metabolism of steroid hormones and xenochemicals including prescription drugs. Nuclear receptor SXR/PXR (steroid and xenobiotic receptor/pregnenolone X receptor) has been shown both biochemically and genetically to...

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Bibliografische gegevens
Gepubliceerd in:Genes Dev
Hoofdauteurs: Xie, Wen, Barwick, Joyce L., Simon, Cynthia M., Pierce, Alexis M., Safe, Stephen, Blumberg, Bruce, Guzelian, Philip S., Evans, Ronald M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cold Spring Harbor Laboratory Press 2000
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Research Paper
Online toegang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC317112/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11114890/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.846800
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