Oncogenic PIK3CA-driven mammary tumors frequently recur via PI3K pathway-dependent and -independent mechanisms

PIK3CA gain-of-function mutations are a common oncogenic event in human malignancy(1–4), making PI3K an attractive target for cancer therapy. Despite the great promise of targeted therapy, resistance often develops, resulting in treatment failure. To elucidate mechanisms of resistance to PI3K-target...

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Bibliographische Detailangaben
Hauptverfasser: Liu, Pixu, Cheng, Hailing, Santiago, Stephanie, Raeder, Maria, Zhang, Fan, Isabella, Adam, Yang, Janet, Semaan, Derek J., Chen, Changzhong, Fox, Edward A., Gray, Nathanael S., Monahan, John, Schlegel, Robert, Beroukhim, Rameen, Mills, Gordon B., Zhao, Jean J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3169724/
https://ncbi.nlm.nih.gov/pubmed/21822287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2402
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