Oncogenic PIK3CA-driven mammary tumors frequently recur via PI3K pathway-dependent and -independent mechanisms

PIK3CA gain-of-function mutations are a common oncogenic event in human malignancy(1–4), making PI3K an attractive target for cancer therapy. Despite the great promise of targeted therapy, resistance often develops, resulting in treatment failure. To elucidate mechanisms of resistance to PI3K-target...

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Detalhes bibliográficos
Main Authors: Liu, Pixu, Cheng, Hailing, Santiago, Stephanie, Raeder, Maria, Zhang, Fan, Isabella, Adam, Yang, Janet, Semaan, Derek J., Chen, Changzhong, Fox, Edward A., Gray, Nathanael S., Monahan, John, Schlegel, Robert, Beroukhim, Rameen, Mills, Gordon B., Zhao, Jean J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3169724/
https://ncbi.nlm.nih.gov/pubmed/21822287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2402
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