Combined inhibition of PI3K and PARP is effective in the treatment of ovarian cancer cells with wild-type PIK3CA genes

OBJECTIVE: Combined inhibition of PI3K and PARP has been shown to be effective in the treatment of preclinical models of breast cancer and prostate cancer independent of BRCA or PIK3CA mutational status. However, the knowledge about this combination treatment in ovarian cancer is limited. The aim of...

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Publicado no:Gynecol Oncol
Main Authors: Wang, Dong, Li, Chengbo, Zhang, Yuan, Wang, Min, Jiang, Nan, Xiang, Lin, Li, Ting, Roberts, Thomas M., Zhao, Jean J., Cheng, Hailing, Liu, Pixu
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5551048/
https://ncbi.nlm.nih.gov/pubmed/27426307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2016.07.092
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