Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability

Our recent work has shown that activation of the Ras/Raf/ERK pathway extends the half-life of the Myc protein and thus enhances the accumulation of Myc activity. We have extended these observations by investigating two N-terminal phosphorylation sites in Myc, Thr 58 and Ser 62, which are known to be...

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Pubblicato in:	Genes Dev
Autori principali:	Sears, Rosalie, Nuckolls, Faison, Haura, Eric, Taya, Yoichi, Tamai, Katsuyuki, Nevins, Joseph R.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Cold Spring Harbor Laboratory Press 2000
Soggetti:	Research Paper
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316970/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11018017/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.836800
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