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Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability

Our recent work has shown that activation of the Ras/Raf/ERK pathway extends the half-life of the Myc protein and thus enhances the accumulation of Myc activity. We have extended these observations by investigating two N-terminal phosphorylation sites in Myc, Thr 58 and Ser 62, which are known to be...

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Udgivet i:Genes Dev
Principais autores: Sears, Rosalie, Nuckolls, Faison, Haura, Eric, Taya, Yoichi, Tamai, Katsuyuki, Nevins, Joseph R.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2000
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316970/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11018017/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.836800
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