Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53

Chk2/hcds1, the human homolog of the Saccharomyces cerevisiae RAD53/SPK1 and Schizosaccharomyces pombe cds1 DNA damage checkpoint genes, encodes a protein kinase that is post-translationally modified after DNA damage. Like its yeast homologs, the Chk2/hCds1 protein phosphorylates Cdc25C in vitro, su...

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Bibliographic Details
Main Authors: Chehab, Nabil H., Malikzay, Asra, Appel, Michael, Halazonetis, Thanos D.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2000
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC316357/
https://ncbi.nlm.nih.gov/pubmed/10673500
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